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Question:
It is estimated that about 80 percent of all cases of peptic ulcer disease are caused by the presence of Helicobacter pylori (H pylori) bacteria. The bacteria damage the protective mucosal lining of the stomach and/or duodenum, allowing it to be damaged by the strong gastric acids used for digestion. Consequently, ulcerations in the mucosal lining and tissue occur. Antibiotic therapy can control the population of H pylori and definitively treat the ulcerative disease. Non-steroidal anti-inflammatory medications, including aspirin, increase acid production and can worsen or exacerbate peptic ulcer disease. While calcium channel blockers can be used in the treatment of gastro-esophageal reflux disease (decrease spasm of the lower esophageal sphincter), they are not indicated in the management of peptic ulcer disease.
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