Where does the chemical digestion of proteins primarily occur within the digestive system?

The chemical digestion of proteins occurs primarily in the stomach and the small intestine. The chemical digestion that occurs in the mouth is primarily that of carbohydrates by salivary amylase. Chemical digestion does not occur in the esophagus or the large intestine. In the stomach, the action of HCl secretion and pepsin chemically digests proteins. Pancreatic enzymes that are secreted into the small intestine, in addition to enzymes secreted by the small intestine itself, further chemically digest proteins in the small intestine.