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Question:
Lithium increases urine output and antagonizes the effects of antidiuretic hormone. In order to avoid dehydration, patients should be instructed to drink 10 - 12 glasses of water each day. Additional fluids will be needed during strenuous activity, in hot weather, or if the patient experiences fluid loss through vomiting or diarrhea. If sodium levels are low, the kidneys will retain lithium, which could result in toxicity.
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