A patient who overdosed on oxycodone is given naloxone. When assessing the patient, the healthcare provider would anticipate which of these clinical manifestations of opioid withdrawal?

Naloxone, an opioid antagonist, will displace opioids at the opioid receptor site. The healthcare provider would expect to observe irritability and nausea. Heart rate and blood pressure will be baseline or elevated, and temperature will be unchanged. Depressed respirations and somnolence are signs of opioid intoxication.